Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health.Approximately 40% of them are lipophilic and are used for treating diseases through various delivery routes, including skin absorption, oral administration, and injection.However, as lipophilic drugs have a low solubility in the human body, dru

Christopher L Bowlus Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA, USA Abstract: Primary biliary cholangitis (PBC), previously known as primary biliary “cirrhosis”, is a rare autoimmune liver disease characterized by the hallmark autoantibodies to mitochondrial antigens and immune-mediated destr

In recent years, the abundance of information in 3D data has made the semantic segmentation of 3D point clouds a topic of great interest.However, current methods often rely solely on the original three-dimensional coordinates of the point cloud as input geometric features, leading to poor generalization performance.Additionally, occlusion of the po

Abstract Methamphetamine addiction is mimicked in rats that self-administer the drug.However, these self-administration (SA) models do not include adverse consequences that are necessary to reach a diagnosis of addiction in humans.Herein, we measured genome-wide transcriptional consequences of methamphetamine SA and footshocks in the rat brain.We t

Anomaly analysis is of great interest to diverse fields, including data mining and machine learning, and plays a critical role in a wide range of applications, such as medical health, credit card fraud, and intrusion detection.Recently, a significant number of anomaly detection methods with a variety of types have been witnessed.This paper intends